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Advances in powder micronization scmmining
Micronization of Proteins by Jet Milling
micronization on the solubility of poorly soluble drugs , the homogeneous distribution Facilitated by advances in molecular biology and immunology and description of diseases at powder injections  and transdermal delivery . For most of these applications proteins
Advanced UV Powder Coatings - PCI Mag
Oct 16, 2006· Ultraviolet (UV) powder coatings combine the advantages of thermosetting powder coatings with those of liquid ultraviolet cure coating technologies. The difference between standard and UV powder coatings is that in UV systems, melting and curing are separated into two distinct processes. Upon exposure to heat, UV curable powder coating particles melt and flow into a homogeneous film
Recent Technology of Powder Metallurgy and Applications
parts consisting of structural and magnetic materials, and powder cores (or soft magnetic cores [SMC]) that feature low core loss in high-frequency regions. 1.2.4 Next-Generation High-Performance Parts We are focusing on micronization as the next-generation technology for the fields of information home appliances and the life sciences.
Technologies to Improve the Solubility, Dissolution and
Micronization of drugs is done by milling techniques using Jet mill, Ball mill, Rotor-stator colloid mill, etc. This approach can reduce particle sizes down to 1 micron. Micronization improved the digestive absorption, and consequently the bioavailability and clinical efficacy of griseofulvin, progesterone, spironolactone and diosmin .
Particle Engineering for Pulmonary Drug Delivery
Jan 24, 2007· With the rapidly growing popularity and sophistication of inhalation therapy, there is an increasing demand for tailor-made inhalable drug particles capable of affording the most efficient delivery to the lungs and the most optimal therapeutic outcomes. To cope with this formulation demand, a wide variety of novel particle technologies have emerged over the past decade.
PHHAARRMMAAC CEEUUTTIICAALL SSCCIIEENNCCEESS
powder .In the treatment of disease, aerosol administration represents a valuable means by which a therapeutic agent may be delivered . ,micronization via jet milling, precipitation, or spray Advantages of Pulmonary Drug Delivery Inhaled drug delivery puts drug where it is needed. It requires low and fraction of oral dose i.e. drug
US6651655B1 - Inhaled vaccines - Google Patents
In a method for creating an immune response, a vaccine is prepared in the form of a dry powder. The powder particles have an aerodynamic particle size range from 1-100 microns. A dose of powder is loaded into a dry powder inhaler. The dose is inhaled with an inspiratory flow rate of less than 60 liters per minute. A mucosal immune response is created via particles of the vaccine material
MICROPHARMACEUTICALS A REVIEW ON MICROSPHERRICAL
micropharmaceuticals - a review on microspherrical applications and recent advances Harsh Rastogi * 1 , Amit Kumar Pandey 2 and Hrishav Das Purkyustha 3 Ram-Eesh Institute of Vocational and Technical Education 1 , Greater Noida - 201310, Uttar Pradesh, India.
Cryo-crystallization under a partial anti-solvent
Industrial research in the field of dry powder inhalation (DPI) technology is still confined to the micronization of active pharmaceutical ingredients (APIs). Earlier studies have identified triboelectric charge as the main reason for the reduced efficiency of most of
US20150068361A1 - Lubricant for powder metallurgy and
A particulate composite lubricant for powder metallurgy comprises: first discrete particles comprising at least about 90 wt % of a fatty primary monoamide wax, being substantially free of fatty bisamide wax, and being at least partially coated with metal oxide nanoparticles and second metal-stearate free discrete particles comprising a fatty bisamide wax.
Conditioning Following Powder Micronization: Influence on
Micronization is a high-energy process that induces changes in the crystallinity of materials. As a result, the crystalline structures on the particles' surface are being destroyed and amorphous areas are formed. After micronization of salbutamol sulfate to be used in dry powder inhalers, only small amounts of amorphous material are produced.
Micronization in food processing: A comprehensive review
Mar 01, 2021· Micronization delayed retrogradation, induced gelatinization, reduced syneresis, decreased fermentation time, produced stable products and improved dissolution rate. These unique changes were found due to decrease in particle size and increase in surface area.
A review on recent technologies for the manufacture of
Powder Technol. 262, 170176 (2014). Crossref , CAS , Google Scholar 163 Lee HJ, Kang JH, Lee HG et al. Preparation and physicochemical characterization of spray-dried and jet-milled microparticles containing bosentan hydrate for dry powder inhalation aerosols .
Hydrothermal Extraction and Micronization of
from other types of biomass and may result in advances in extraction technology to obtain plant biomass components. (Wasser 2002). In this work, HCW extraction and micronization of polysac-charides from G. lucidum were demonstrated in a single step process. Because of its instantaneously obtain a powder due to heat and mass transfers
A Kinetic Study of Micronization Grinding of Dry Mica in a
The micronized powder was investigated by means of differential thermal and thermogravimetric analyses, analysis of the degree of micronization, the specific surface area analysis, and X-ray diffraction analysis. The achieved results pointed out that dry mica micronization grinding which exceeds 360 minutes is recommended for this type of mill.
RJPT - Micronization of BCS ClassII Drugs by Various
Poor aqueous solubility of a drug is an industry wide issue for pharmaceutical scientists in dosage form development. Numerous approaches have been developed for solubility enhancement of biopharmaceutical class II drugs (low solubility and high permeability). Obviously poorly water soluble drugs show many problems in formulating them in dosage forms.
Mithun V Varghese, PhD - Formulation specialist - Dr
Developed platform technologies for dry powder inhalation drug delivery. Through cryo-crystal engineering directly inhalable, purely crystalline API was synthesized, which was found to be a better technology than spray drying or micronization methods.
Effect of micronization on Physicochemi cal Properties of
Effect of micronization on Physicochemi cal Properties of Tapioca Starch Yang Hu 1, 2, a, Wen Xia 1, b,*, Jihua Li 1, c, Fei Wang 1, d, Xiaoyi Wei 1, e, Yanyun Lin 1,f 1Key Laboratory of Tropical Crop Products Processing of Ministry of Agriculture, Agricultural Products Processing Research Institute, Chinese Academy of Tropical Agricultural Sciences,
Spray-Dried Powders for Pulmonary Drug Delivery - Critical
Powders for inhalation are traditionally prepared using a destructive micronization process such as jet milling to reduce the particle size of the drug to 25 μm. The resultant particles are typically highly cohesive and display poor aerosolization properties, necessitating the addition of a coarse carrier particle to the micronized drug to
About Us Midas Microtech Engineering Private Limited
With a strong inclination towards Research and Development from the very beginning, we aim to improve our customers product through advances in micronization technology. The performance of pharmaceutical micronizers is primarily evaluated based on Particle Size Analysis by Laser Diffraction.
Powder Crusher Equipment For Powder Substances
Crushing equipment,Ore beneficiation equipment,Powder Quartz Powder Ball Mills In Kadapa In Ap. The Quartz Powder range can be acquired crushing hammer mills and quartz crusher. Ball mills are machines whose functions are to grind substances into powder advances in powder micronization - BINQ Mining. Advances in Powder Micronization
Hydrothermal extraction and micronization of
Full Article. Hydrothermal Extraction and Micronization of Polysaccharides from Ganoderma lucidum in a One-Step Process Yui Matsunaga, a,b Wahyudiono, b Siti Machmudah, b,c R. Askin, a Armando T. Quitain, a Mitsuru Sasaki a and Motonobu Goto b Ganoderma lucidum (G. lucidum) is a mushroom-forming white rot fungus that contains a wide variety of bioactive components (glucans).
TECHNOLOGICAL ADVANCES IN PALM-BASED FOOD
TECHNOLOGICAL ADVANCES IN PALM-BASED FOOD FORMULATIONS Nor Aini Idris Rafidah Abd. Hamid and Miskandar Mat Sahri Malaysian Palm Oil Board, P. O. Box 10620, 50720 Kuala Lumpur, Malaysia Palm oil The Sustainable 21st Century Oil 23-24 March, London
Mithun V Varghese, PhD - Formulation specialist - Dr
Industrial research in the field of dry powder inhalation (DPI) technology is still confined to micronization of active pharmaceutical ingredient (API). Earlier studies have identified
Modeling the Gas Antisolvent Recrystallization Process
Jun 26, 2002· A mathematical model describing the gas antisolvent recrystallization process has been developed. In this process, precipitation of a solid from solution is triggered through the addition of a dense gas antisolvent under near-critical conditions. The possibility of controlling the particle size distribution of the produced microparticles makes it rather attractive for pharmaceutical and
FORMULATION AND PRODUCT DEVLOPMENT OF DRY
Dry powder inhalers contain the drug in a powder formulation, where drug particles (< 5 μm) are blended with a suitable large carrier (e.g. lactose) to improve flow properties and dose uniformity and drug powders are delivered deep into the lung via a device known as dry powder inhaler (DPI).
Crystals and Crystallization in Drug Delivery Design
Feb 17, 2021· Design (CG&D). Ongoing advances in our ability to understand, predict, and control the solid form and solid-state properties of pharmaceuticals are also extremely timely, not least the impressive progress in computational crystal structure calculation methods. MP focuses on the molecular mechanistic understanding of drug delivery and drug delivery
Development and characterization of meropenem dry powder
Sep 25, 2020· Particle size and homogeneity of MPN powder formulations. The desired particle size of MPN was achieved by micronization and was confirmed by SEM and TEM in the range of 0.22 µm. The aerodynamic particle size was calculated to be (1.83 ± 0.02) µm (Peng et al., 2016). The drug particles were mixed with the excipients and the homogeneity of
(PDF) The role of particle engineering in relation to
The aim of this study is to formulate cetrorelix with a high fine particle fraction as a powder for inhalation using three different methods for micronization, namely milling, as an example of a standard technique, and spray drying and spray freeze drying as examples of
Development and Investigation of Dry Powder Inhalers for
drug when in contact with the liquids lining the lung. The micronization by means of spray drying process and addition of opportune additives able to improve powder wettability seem to be a valid strategy for the formulation of an efficacious dry powder inhaler.
(PDF) Efavirenz Dissolution Enhancement I: Co-Micronization
The improvements may be explained by the hypothesis that formation of a hydrophilic layer on the surface of the micronized drug increases the wettability of the system formed, corroborated by
Thomas Lamotte - Senior Process Engineering Specialist
Dec 02, 2019· About Process Engineering expert, 12 years of experience in food and chemical processes, holding 2 Masters in Engineering. I have extensive experience in international projects, dealing with multicultural environment, having carried out missions in 25+ factories worldwide for process design, commissioning / start-up lead or to provide training.
Milling and Micronizing Pharmaceutical Powders in High
Jul 28, 2020· Micronization is a common process in the pharma industry throughout the drug development cycle, from chemical synthesis to oral solid dosage plans for patients. This process is also known to require a lot of energy, and very often creates an
Research Article A Kinetic Study of Micronization Grinding
ned properties and characteristics of mica powder. e micronization grinding of dry mica was performed in four time periods: , , , and minutes. e micronized powder was investigated by means of di erential thermal and thermogravimetric analyses, analysis of the degree of micronization, the speci c surface area analysis, and X-ray di raction analysis.
Advances in the Functional Characterization and Extraction
Sep 19, 2015· Advances in the Functional Characterization and Extraction Processes of Dietary Fiber Advances in the Functional Characterization and Extraction Processes of Dietary Fiber Tejada-Ortigoza, Viridiana; Garcia-Amezquita, Luis; Serna-Saldívar, Sergio; Welti-Chanes, Jorge 2015-09-19 00:00:00 Dietary fiber has attracted interest due to its well-known physiological and functional properties.
Recrystallization and Micronization of 10
Dec 20, 2011· Recrystallzation and micronization of 10-hydroxycamptothecin (HCPT) was investigated in a supercritical antisolvent (SAS) process using the mixture of dichloromethane and ethanol as the solvent, with supercritical carbon dioxide (sc-CO2) as the antisolvent. Five factorsi.e., the volume ratio of the mixed solvent, the concentration of HCPT in the solution, the flow rate of HCPT solution, the
Advances in Powder Micronization Technology for the
Advances in Powder Micronization Technology for the Pharmaceutical Industry The demand for pharmaceutical materials including finely ground active subdtances and excipients is geowing.
Chemical recycling of mixed plastics of pyrolysis
María A. Diez, Ramón Alvarez, Advances in the recycling of plastic wastes for metallurgical coke production, Journal of Material Cycles and Waste Management, 10.1007/s10163-012
Advanced design and development of nanoparticle
lactose carrier-free dry powder inhalation aerosols Compared to micronization techniques that are currently used to prepare the powder formulation in the dry powder Paper RSC Advances Open Access Article. Published on 17 November 2020. Downloaded on 4/27/2021 10:40:09 AM.
Micronization in the pharmaceutical industry
Micronization is the process of reducing a bulk solid materials particle size to the micron or submicron level. This article discusses dry powder milling techniques and their effectiveness for micronization, specifically in the pharmaceutical industry. The article looks at how mechanical, ball, and jet mills stack up against each other.
Micronization: a method of improving the bioavailability
Fine grinding mills are use to micronize powders: either jar mills or fluid energy mills. Theses processes were applied to griseofulvin, progesterone, spironolactone and diosmin. For each drug, micronization improved their digestive absorption, and consequently their bioavailability and
Pharmaceutical particle technologies: An approach to
Dec 01, 2014· The particle size reduction techniques involving powder and particle technology are discussed in this review. 2.1. Mechanical micronization. Micronization is a conventional technique for the particle size reduction and is a commonly used method for increasing solubility of BCS class II drugs .
Micronization and Agglomeration: Understanding the Impact
Jan 22, 2020· Model API (micronized and unmicronized) were characterized using X-ray powder diffractometry (XRPD), differential scanning calorimetry (DSC), Raman imaging, optical profilometry, and miniaturized dissolution apparatuses. Two-way ANOVA with replication was used to interpret results with statistical significance.
Conditioning Following Powder Micronization: Influence on
Recent advances in powder production and particle engineering techniques are also assessed, aiming to develop new inhaled powder formulations or improve the aerosolisation efficiency of existing
An overview of size reduction technologies in the REVIEW
theories, techniques, advances, and pharmaceutical applications of size reduction technology. Key words: Micronization, milling, particle size, size reduction INTRODUCTION Size reduction is a process of reducing large solid unit masses (vegetable or chemical substances) into small unit masses, coarse particles or fine particles.
Technologies to Improve the Solubility, Dissolution and
Micronization improved the digestive absorption, and consequently the bioavailability and clinical efficacy of griseofulvin, progesterone, spironolactone and diosmin. Figure 1 presents the schematic presentation of Jet mill, which is commonly used for micronization. Figure 1: Schematic presentation of Jet Mill.
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